Clarithromycin is BCS class II drug having poor water solubility and used as antibiotics for various pathogenic diseases. It is well absorbed from GI track and has good stability in acidic media. It has half life of 3 to 4 hrs. Which make it suitable for incorporation in a bioadhesive gastroretentive dosage form for extended duration of time. Matrix tablets of Clarithromycin were formulated using bioadhesive polymers namely HPMC K100M and Psyllium husk. The prepared tablets were evaluated for weight variation, thickness, hardness, content uniformity, swelling index, bioadhesive force and in vitro drug release. All the formulations showed good bioadhesion strength and swelling. Swelling studies indicated significant water uptake and contributed in drug release. From among all the developed formulations, as F9 has highest bioadhesive strength (322.41). Formulation of F9 which were formulated by using polymers, HPMC K100M and Psyllium husk provided controlled release of Clarithromycin over the period of 24 hrs. The cumulative % of drug release of formulation F9 was 95.67 %. Thus it can be concluded that a gastroretentive bioadhesive tablet of clarithromycin can give extended duration of drug action, loading to better patient compliance.
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